Like supplements, OTC female arousal topicals often rely on botanical ingredients and amino acids.

But prescription topicals, like Cake Meds’ O-Cream Rx and Wisp’s OMG! Cream, add drugs, such as sildenafil, to the mix. Like the tadalafil in the Libido Lift Rx pill mentioned above, the sildenafil in these two prescription topicals is off-label, but a small study from 2020 found that women who used sildenafil cream reported “clinically significant increases” in arousal versus the results from no cream and placebo cream.9 At the time of this writing, the closest thing to an “instant” female arousal pill is Cake Meds’ Libido Lift Rx, which is a dissolvable prescription tablet containing tadalafil that should work in about 30 minutes and may be effective for up to 36 hours.67 Otherwise, pills tend to take the longest to start working (anywhere from a couple of weeks to a month or so).

• Avoid endocrine disruptors found in plastics.
• Vitamin B complex can support energy and desire.
• A herbal blend containing ginseng may be beneficial.
• Consider natural hormone-balancing supplements.
• Small doses of testosterone therapy may be considered.
• Playing romantic music can set a sensual mood.
• Ensuring privacy can improve sexual confidence.
• Counseling or therapy can address emotional barriers.

The FDA-approved pill, Addyi, and OTC supplements have the potential to promote the longest-lasting benefits, however, as they build up and continue to be in your system. If pills don’t interest you, then topicals, such as OMG!

Frequently Asked Questions (FAQs)

Cream and Jolt Gel, or the prescription injection, Vyleesi, could be good alternatives. These also all work within the hour, but the effects only last a short amount of time. Topicals can be effective for around 20-60 minutes, and Vyleesi content in the body peaks at around one hour before falling again.57 Even with combining Addyi and Vyleesi, there don’t appear to be any known risks of mixing these two approaches together at the time of this writing. If this changes, we’ll update this guide with an appropriate warning.

But, for now, it appears safe to use a pill or supplement to promote potential long-term benefits while also using female arousal topicals for an extra, more timely boost.

Libido Supplements for Women: What the Evidence Supports

Nitric oxide is also believed to play a major role in the smooth muscle relaxation of sexual arousal.14 Additionally, the increase in blood circulation from nitric oxide’s vasodilation properties can reduce vaginal dryness, as vaginal lubrication is actually ultra-filtered blood.19 L-Citrulline is partially converted to L-arginine, which is then converted to nitric oxide, meaning that this amino acid can also promote NO production.10 Research on L-citrulline for sexual dysfunction usually involves it being used with L-arginine, and most of the research on L-citrulline alone involves men. For example, one study found that 1.5g (1,500mg) of L-citrulline appears to be a safe and effective alternative treatment for mild to moderate erectile dysfunction.20 However, since researchers note that this outcome is likely due to increased NO production, it can be assumed that women may also experience similar benefits from L-citrulline. L-Carnitine is an amino acid that plays a critical role in energy production — it transports fatty acids to the mitochondria (that “powerhouse of the cell” you likely heard about in science class) to be turned into a form of energy called adenosine triphosphate (ATP).21 This amino acid also shows the potential to improve exercise performance while reducing oxidative stress in response to resistance training.22 This could be why Promescent states that VitaFLUX may be able to help you recover more quickly from injury or exhaustion. And, while there isn’t much research on L-carnitine and sexual function, one study on fildena professional 100 lambs found that “a disruption in carnitine homeostasis” led to a reduction in bioavailable NO. In this study, maintaining carnitine homeostasis kept ATP levels adequate, which also appeared to have a positive effect on preserving Hsp90 activity.

Original Harmonizing Lube

This “molecular chaperone” can help support hormone signaling pathways (such as those for estrogen and testosterone).23 The research on magnesium and sexual function is sparse, but there is definitely some potential for it to be a beneficial addition. One study on the magnesium levels of men reporting premature ejaculation (PE) found that lower levels were “significantly related” to the condition.24 However, more research is needed on the relationship between magnesium and PE. A separate study on the role magnesium plays in hypertension and cardiovascular disease has information that’s actually more closely related to the potential benefits for female sexual dysfunction than the other study. Researchers note that the mineral mimics the effects of a calcium channel blocker — a drug for lowering blood pressure that allows “blood vessels to relax and open.” This results in increased nitric oxide production and improved blood flow, similar to the amino acids in the VitaFLUX formula.25 26 A study from 2021 found that zinc supplementation for postmenopausal women whose serum zinc levels were low resulted in dramatic improvements in desire for sex and sexual pleasure; vaginal lubrication improved, while pain diminished. This may be due to the resulting increase in testosterone found by the researchers.27 Additionally, one study on zinc and nitric oxide notes that both are heavily involved in the various signal transduction pathways of the body, describing them as “intersecting.”28 As with all treatments, VitaFLUX may not work for everyone or provide the same potential benefits to everyone. L-Arginine, L-citrulline, and L-carnitine may improve blood flow to the genitalia Zinc and magnesium could help physical arousal in people with deficiencies Capsules are vegan-friendly (corn- and plant-based gelatin) Ingredients should be generally safe for most people 60-day money-back guarantee for new customers Subscribe for 15% off of recurring deliveries Save $5 when you visit Promescent using our links on this page Unsafe for pregnant or breastfeeding individuals and those with corn allergies Dose is six capsules daily (three pills, twice a day) L-arginine may trigger a herpes flare-up Promescent made its name by pioneering delay sprays to help men overcome premature ejaculation, but the company has since greatly expanded its catalog of sexual health products.

Learn More From Our Specialists

Pivoting back to VitaFLUX, you can purchase this supplement as either a single bottle or a bulk pack of three. Both options are available as single purchases or subscriptions. The chart below breaks down the details. (The single purchase pricing includes our $5 off discount.) If you prefer shopping on Amazon, you can find VitaFLUX there as well, but it appears to mainly be sold by third-party sellers (not Promescent or Amazon) so the quality — and authenticity — of the product can’t always be guaranteed.

The Silent Role of Thyroid Health in Women’s Libido

Its VitaFLUX supplement is available for men and women (both are the exact same except for label color), but in this guide, we'll focus on what this supplement might do for those with female anatomy.

The Bottom Line

If this supplement is right for blue tablets you and your body, you’ll likely start to see some improvements after around a month or so. If there are no noticeable changes whatsoever after your first bottle is gone (30 days of use), then it may be time to try something else. The ingredients in VitaFLUX fall well below established tolerable upper limits, so the product should generally be safe for most healthy adults. Side effects of amino acids at the doses present in this supplement are more likely to be mild and may include gastrointestinal upset (like nausea and diarrhea).61 However, we always recommend speaking with your doctor before trying a new supplement to make sure it’s a safe choice for you. The list below details some particular instances where VitaFLUX may not be ideal: Taking L-arginine could trigger a herpes flare-up (both HSV-1 and HSV-2).3 L-carnitine can possibly interact with some medications: doxorubicin, thyroid hormones, and blood thinners.4 Due to nitric oxide's vasodilating effects, this product might not be safe for people taking certain medications, such as those for blood pressure.63 Zinc may interact with antibiotics, penicillamine, and thiazide diuretics.29 Although the zinc content is far below the tolerable upper limit for adults (40mg daily), be careful not to over-supplement if you take another supplement containing zinc.

Non-hormonal medications for low desire

Exceeding the upper limit of zinc for an extended period of time is unsafe and could lead to a deficit of copper in your body, among other things.30 Also, individuals who are pregnant or breastfeeding should avoid taking VitaFLUX. Promescent used to sell VitaFLUX for Women in both capsule and powder form, but the latter seems to have been discontinued since we last checked in with the company. Unfortunately, this means that those who dislike the idea of taking six capsules daily — or those who simply can’t swallow pills — may need to look elsewhere. This could mean trying topicals, like Wisp’s OMG! Cream, or something like Cake’s Libido Lift Rx, which is a sublingual tablet that dissolves under your tongue. Promescent claims VitaFLUX for Women may help: Aid in faster recovery pills to increase sex drive male from injury or exhaustion We’ll investigate the validity of these claims next, but it seems like Promescent intends for VitaFLUX to boost both sexual and overall wellness. This is similar to how Leading Edge Health — the company behind HerSolution — markets its female libido supplements. Before delving into the supplement’s potential efficacy, let’s first take a quick look at the active ingredients in VitaFLUX, which include: Though it has more of them, VitaFLUX isn’t the only product in this guide to use amino acids to support sexual health. For example, both Jolt Gel (a topical) and Hello Cake’s Drive For Her (a supplement) also contain L-arginine.

Now, let’s break down how (or if) these ingredients can potentially provide the benefits suggested by Promescent. A systematic review of research studies suggests that L-arginine (along with L-citrulline) can result in greater sexual arousal and satisfaction for pre-, peri-, and postmenopausal women who have HSDD or a related concern. The effective daily dosages that led to promising results within the examined studies were similar to the arginine dose delivered daily by VitaFLUX.10 These positive results are likely due to the fact that L-arginine is a precursor of nitric oxide (NO), which promotes better blood flow throughout the body (including to the genitals). Nitric oxide is also believed to play a major role in the smooth muscle relaxation of sexual arousal.14 Additionally, the increase in blood circulation from nitric oxide’s vasodilation properties can reduce vaginal dryness, as vaginal lubrication is actually ultra-filtered blood.19 L-Citrulline is partially converted to L-arginine, which is then converted to nitric oxide, meaning that this amino acid can also promote NO production.10 Research on L-citrulline for sexual dysfunction usually involves it being used with L-arginine, and most of the research on L-citrulline alone involves men. For example, one study found that 1.5g (1,500mg) of L-citrulline appears to be a safe and effective alternative treatment for mild to moderate erectile dysfunction.20 However, since researchers note that this outcome is likely due to increased NO production, it can be assumed that women may also experience similar benefits from L-citrulline. L-Carnitine is an amino acid that plays a critical role in energy production — it transports fatty acids to the mitochondria (that “powerhouse of the cell” you likely heard about in science class) to be turned into a form of energy called adenosine triphosphate (ATP).21 This amino acid also shows the potential to improve exercise performance while reducing oxidative stress in response to resistance training.22 This could be why Promescent states that VitaFLUX may be able to help you recover more quickly from injury or exhaustion. And, while there isn’t much research on L-carnitine and sexual function, one study on fildena professional 100 lambs found that “a disruption in carnitine homeostasis” led to a reduction in bioavailable NO. In this study, maintaining carnitine homeostasis kept ATP levels adequate, which also appeared to have a positive effect on preserving Hsp90 activity. This “molecular chaperone” can help support hormone signaling pathways (such as those for estrogen and testosterone).23 The research on magnesium and sexual function is sparse, but there is definitely some potential for it to be a beneficial addition.

• Use of natural aphrodisiacs like oysters is common.
• Ensuring skin health influences sexual confidence.
• Managing anxiety can directly impact desire.
• Herbal capsules may improve sexual energy.
• Maintaining a positive body image boosts libido.
• Supportive friendships encourage emotional openness.
• Avoiding excessive sugar intake benefits hormonal health.
• Listening to sensual music enhances arousal.

One study on the magnesium levels of men reporting premature ejaculation (PE) found that lower levels were “significantly related” to the condition.24 However, more research is needed on the relationship between magnesium and PE. A separate study on the role magnesium plays in hypertension and cardiovascular disease has information that’s actually more closely related to the potential benefits for female sexual dysfunction than the other study. Researchers note that the mineral mimics the effects of a calcium channel blocker — a drug for lowering blood pressure that allows “blood vessels to relax and open.” This results in increased nitric oxide production and improved blood flow, similar to the amino acids in the VitaFLUX formula.25 26 A study from 2021 found that zinc supplementation for postmenopausal women whose serum zinc levels were low resulted in dramatic improvements in desire for sex and sexual pleasure; vaginal lubrication improved, while pain diminished. This may be due to the resulting increase in testosterone found by the researchers.27 Additionally, one study on zinc and nitric oxide notes that both are heavily involved in the various signal transduction pathways of the body, describing them as “intersecting.”28 As with all treatments, VitaFLUX may not work for everyone or provide the same potential benefits to everyone. If this supplement is right for blue tablets you and your body, you’ll likely start to see some improvements after around a month or so.

2. FDA-Approved Prescription Options

But, for now, it appears safe to use a pill or supplement to promote potential long-term benefits while also using female arousal topicals for an extra, more timely boost. L-Arginine, L-citrulline, and L-carnitine may improve blood flow to the genitalia Zinc and magnesium could help physical arousal in people with deficiencies Capsules are vegan-friendly (corn- and plant-based gelatin) Ingredients should be generally safe for most people 60-day money-back guarantee for new customers Subscribe for 15% off of recurring deliveries Save $5 when you visit Promescent using our links on this page Unsafe for pregnant or breastfeeding individuals and those with corn allergies Dose is six capsules daily (three pills, twice a day) L-arginine may trigger a herpes flare-up Promescent made its name by pioneering delay sprays to help men overcome premature ejaculation, but the company has since greatly expanded its catalog of sexual health products. Its VitaFLUX supplement is available for men and women (both are the exact same except for label color), but in this guide, we'll focus on what this supplement might do for those with female anatomy. Promescent claims VitaFLUX for Women may help: Aid in faster recovery pills to increase sex drive male from injury or exhaustion We’ll investigate the validity of these claims next, but it seems like Promescent intends for VitaFLUX to boost both sexual and overall wellness. This is similar to how Leading Edge Health — the company behind HerSolution — markets its female libido supplements.

Fueling your desire by letting your imagination speak!

Before delving into the supplement’s potential efficacy, let’s first take a quick look at the active ingredients in VitaFLUX, which include: Though it has more of them, VitaFLUX isn’t the only product in this guide to use amino acids to support sexual health. For example, both Jolt Gel (a topical) and Hello Cake’s Drive For Her (a supplement) also contain L-arginine. Now, let’s break down how (or if) these ingredients can potentially provide the benefits suggested by Promescent. A systematic review of research studies suggests that L-arginine (along with L-citrulline) can result in greater sexual arousal and satisfaction for pre-, peri-, and postmenopausal women who have HSDD or a related concern. The effective daily dosages that led to promising results within the examined studies were similar to the arginine dose delivered daily by VitaFLUX.10 These positive results are likely due to the fact that L-arginine is a precursor of nitric oxide (NO), which promotes better blood flow throughout the body (including to the genitals). If there are no noticeable changes whatsoever after your first bottle is gone (30 days of use), then it may be time to try something else. The ingredients in VitaFLUX fall well below established tolerable upper limits, so the product should generally be safe for most healthy adults. Side effects of amino acids at the doses present in this supplement are more likely to be mild and may include gastrointestinal upset (like nausea and diarrhea).61 However, we always recommend speaking with your doctor before trying a new supplement to make sure it’s a safe choice for you.

Limit your alcohol intake

Like supplements, OTC female arousal topicals often rely on botanical ingredients and amino acids. But prescription topicals, like Cake Meds’ O-Cream Rx and Wisp’s OMG! Cream, add drugs, such as sildenafil, to the mix. Like the tadalafil in the Libido Lift Rx pill mentioned above, the sildenafil in these two prescription topicals is off-label, but a small study from 2020 found that women who used sildenafil cream reported “clinically significant increases” in arousal versus the results from no cream and placebo cream.9 At the time of this writing, the closest thing to an “instant” female arousal pill is Cake Meds’ Libido Lift Rx, which is a dissolvable prescription tablet containing tadalafil that should work in about 30 minutes and may be effective for up to 36 hours.67 Otherwise, pills tend to take the longest to start working (anywhere from a couple of weeks to a month or so). The FDA-approved pill, Addyi, and OTC supplements have the potential to promote the longest-lasting benefits, however, as they build up and continue to be in your system.

2. Consider Prescription Medications

If pills don’t interest you, then topicals, such as OMG! Cream and Jolt Gel, or the prescription injection, Vyleesi, could be good alternatives. These also all work within the hour, but the effects only last a short amount of time. Topicals can be effective for around 20-60 minutes, and Vyleesi content in the body peaks at around one hour before falling again.57 Even with combining Addyi and Vyleesi, there don’t appear to be any known risks of mixing these two approaches together at the time of this writing. If this changes, we’ll update this guide with an appropriate warning. The list below details some particular instances where VitaFLUX may not be ideal: Taking L-arginine could trigger a herpes flare-up (both HSV-1 and HSV-2).3 L-carnitine can possibly interact with some medications: doxorubicin, thyroid hormones, and blood thinners.4 Due to nitric oxide's vasodilating effects, this product might not be safe for people taking certain medications, such as those for blood pressure.63 Zinc may interact with antibiotics, penicillamine, and thiazide diuretics.29 Although the zinc content is far below the tolerable upper limit for adults (40mg daily), be careful not to over-supplement if you take another supplement containing zinc. Exceeding the upper limit of zinc for an extended period of time is unsafe and could lead to a deficit of copper in your body, among other things.30 Also, individuals who are pregnant or breastfeeding should avoid taking VitaFLUX. Promescent used to sell VitaFLUX for Women in both capsule and powder form, but the latter seems to have been discontinued since we last checked in with the company.

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What causes low libido?

Unfortunately, this means that those who dislike the idea of taking six capsules daily — or those who simply can’t swallow pills — may need to look elsewhere. This could mean trying topicals, like Wisp’s OMG! Cream, or something like Cake’s Libido Lift Rx, which is a sublingual tablet that dissolves under your tongue. Pivoting back to VitaFLUX, you can purchase this supplement as either a single bottle or a bulk pack of three. Both options are available as single purchases or subscriptions. The chart below breaks down the details.

• Phytoestrogens in flaxseeds influence sexual health.
• Saffron supplements have been linked to enhanced desire.
• Laughter and positive mood improve sexual responsiveness.
• Vitamin E acts as an antioxidant supporting hormonal health.
• Gingko biloba may improve blood flow to genital areas.
• Herbal tinctures can promote sexual vitality.
• Consuming honey and cinnamon might boost libido.
• A healthy climate at home encourages intimacy.

(The single purchase pricing includes our $5 off discount.) If you prefer shopping on Amazon, you can find VitaFLUX there as well, but it appears to mainly be sold by third-party sellers (not Promescent or Amazon) so the quality — and authenticity — of the product can’t always be guaranteed.

• Incorporate herbs like Tribulus in daily routines.
• Maintain hormonal health through regular checkups.
• Support adrenal health with adaptogens.
• Use visual and auditory stimuli to arouse.
• Focus on emotional intimacy as much as physical.
• Consider consulting a sex therapist if needed.
• Avoid negative body talk to boost confidence.
• Educate yourself about female sexual health.